Rumors the ranitidine reasons false positives for meth in drug screening have actually circulated for years, yet the problems under i beg your pardon this would happen are exceptionally rare.

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Published7 February 2018

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Zantac (ranitidine) or similar acid reflux medications reason users come falsely test optimistic for meth use.

What\"s TrueStudies of a currently discontinued urine testing protocol because that amphetamines did display that, under rare and details circumstances, false positives could be led to by the mountain reflux medication Zantac (ranitidine); over there is, together well, minimal evidence of comparable false positives using one check still ~ above the market, yet the event is rarely and likewise subject to details conditions.

What\"s False

Zantac, ranitidine, or various other related medicines consistently cause false positives on drug tests.

In 2016, a insurance claim that use of the over-the-counter mountain reflux medicine Zantac (ranitidine) had developed a false positive an outcome for methamphetamines showed up on social media; that claim resurfaced again in 2018.

As a followup come this report, researchers conducted a rather larger-scale research in 1991 to investigate the possibility of false positives. They concluded that, while possible, it required extremely particular circumstance:

We have evidenced that ranitidine can offer a positive an outcome with the monoclonal EMIT d.a.u, assay, however this occurs just with high urine levels current in a small percentage that patients in ~ a short duration of time after ~ a ranitidine dose.

Beckman Coulter AMPH assay is still prone to far-reaching interference with ranitidine, presumably because of antibody cross-reactivity, whereas the Siemens EMIT II to add assay is cost-free from such interference.

The feasible mechanism because that false positives, in both cases, is not the chemistry similarity the Zantac to amphetamines, however through the existence of unintended reactions between Zantac and the chemicals meant to connect with amphetamines, a difficulty known as cross-reactivity, i m sorry is described in a 2004 review on the topic:

Substances that alter the measurable concentration of the analyte in the sample or transform antibody binding have the right to potentially result in assay interference. Analytical interference is characterized as the impact of a substance current in the sample that transforms the correct worth of the result.

With this information in mind, we rate the case that Zantac causes false positives for methamphetamine a mixture because, if there continues to be a possibility that at the very least one check on the market could conceivably produce a false positive for amphetamines indigenous Zantac, the problems that call for such a an outcome are rare and also most tests do not endure from this potential problem. Additionally, the check that generated the many attention in terms of potential false positives is no much longer in regular use.

Grinstead, Gregory F. “Ranitidine and High concentrations ofPhenylpropanolamlne Cross reaction in the EMIT Monoclonal Amphetamine/Methamphetamine Assay.” Clinical Chemistry. September 1989.

Poklis, Alphonse, et al. “Ranitidine Interference with the Monoclonal EMIT d.a.u.Amphetamin ethamphetamine Immunoassay.” Journal of analysis Toxicology. March 1991.

Liu, L., et al. “Ranitidine Interference with Standard Amphetamine Immunoassay.” Clinical Chimica Acta. 19 September 2015.

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Tate, Jill, and Ward, Gred. “Interferences in Immunoassay.” The Clinical Biochemist Reviews. May 2004.